Template-Free Synthesis and Control Drug Release of Calcium Carbonate-Hydroxylapatite Composite

We employed Gas expanded liquids (GXLs) technology to synthesize calcium carbonate-hydroxylapatite composite (CaCO3-HAp) nanoparticles and investigated the effects of reaction parameters on properties composites as well performance drug delivery agent using ibuprofen a model in simulated gastric fluid. Separately, carbonate hydroxylapatite have been used extensively pharmaceutical systems (DDS). However, both CaCO3 HAp individual draw-backs limitations applications. The results showed that had good thermal stability better surface area pore (volume size) properties. Studies fluid revealed promoted dissolution outstandingly. Whereas low pressure loaded quicker relief potential (92% release) 30 minutes with control release over desirable time frame (3h, 20 min), high also exhibited (80% but remarkable (6h, 40 min). implication is if patient administered into synthesized at (10.0 MPa), will experience ibuprofen) min which be sustained for almost 3.5 hours. Similarly, (17.0 MPa) provide however, this case longer period; about 6.5 Therefore, tremendous effect can effective system (DDS) drugs similar characteristics.